Research Studies

The purpose of this study is to explore whether a specific therapy that provides psychoeducation to people who are at risk for psychosis is effective and acceptable. This study involves completing an interview about your symptoms and experiences to determine if you are eligible. If you are eligible, you will participate in five 1-hour sessions of a psychoeducational therapy, and complete questionnaires and interviews at two time points (before and after the therapy) to gather more information about your symptoms and experiences. During the COVID-19 pandemic and when social distancing requirements are in place, study visits may take place over a HIPAA-compliant and free telehealth platform.

Subjects will be compensated $10 per visit, and an additional $15/hour at each of the two evaluation sessions.

Please contact Dr. Shaynna Herrera at shaynna.herrera@mssm.edu. More information can be found here:

https://www.cuemountsinai.org

https://www.mountsinai.org/care/behavioral-health/services/schizophrenia/psychosis-risk

When does the post expire? July 2021

We are conducting this study to discover if there is an intersection between psychosis causing a form of trauma for those experiencing it. The participants will fill out a survey about their experiences. There will be an optional second part that includes being interviewed, but that is something individuals will opt into voluntarily at the end of the survey.

Eligibility: anyone who has or is actively experiencing psychosis.

Every 10th participant will be compensated with $50 up to 5 gift cards.

Click here to begin the survey: https://usf.az1.qualtrics.com/jfe/form/SV_42FdB0vsReyHSUR

If you have any further questions, please contact Shannon Pagdon at ShannonPagdon@gmail.com or by phone at (347) 768-2721.

There is no current expiration for the survey. We are looking for at least 100 participants, so however long it takes to get there will be the determining factor.

The purpose of this study is to compare the effects of Mindfulness-Based Stress Reduction (MBSR) with Escitalopram (Lexapro) for treating anxiety disorders, specifically social anxiety disorder, generalized anxiety disorder, panic disorder, and agoraphobia. Participants are randomized into two 8-week virtual treatments: (1) MBSR and (2) escitalopram.

Virtual MBSR intervention will include a weekly 2.5 hour class for 8 weeks. The intervention will also include a 1-day virtual (7 hours) retreat on a weekend at the end of the program. Participants will also be asked to engage in 45 minutes of practice at home on a daily basis, as well as informal practice assignments that instruct participants to bring mindfulness to current daily activities.

Participants will receive free treatment no matter which arm they are assigned to. They will need to complete a 3-hour screening visit, a 1-hour baseline visit, and 5-6 study assessment visits. There will also be follow-up visits at 3 months and 6 months.

Participants will receive $20 per study visit, not including screening. If participants complete the study, they will receive $160.

For more information, please call 1-888-44-WORRY or email anxietystudy@nyumc.org. This study is run by NYU Langone Health.

Post expires 11/1/20.

The Child Coping Study is interested in learning more about how NYC children cope with stressful events, with a focus on children ages 6-11 years (or elementary school age). We are looking for parents/guardians of children in this age range to enroll in our study. Your participation will help us learn more about the experiences and coping skills of NYC children, as well as how parents may help children cope with stress. The research will cover topics like violence that your child may have experienced or heard about, as well as the impact of the COVID-19 pandemic on your family. We are interested in learning about the ways that NYC children cope with stressful events that are most helpful in their well-being.

Participating families can complete our questionnaire online or over the phone with a member of our research staff. Participation is voluntary and the survey may take 15-30 minutes. This study is non-therapeutic.

In appreciation for your participation, you may enter into a lottery to receive a $50 gift card (your choice of Visa, Amazon, or Target). If selected, you will receive this gift card by September 2020 or earlier.

If you would like to be involved in this study, please complete our eligibility survey at the following link: Child Coping Study

If you have further questions, please call Julie Neuspiel at (914)269-8843 or email us at ChildCopingUMB@gmail.com.

This is a dissertation study funded by the University of Massachusetts Boston. This study will be recruiting until September 2020.

Social function relies on language and communication between individuals and others. This includes speaking in a way that makes it easy for people to understand what we are saying, and also being able to read other people’s emotions and intentions in their speech and facial expression.

For many people who have had psychotic-like experiences, they have some struggles with getting their point across, or in understanding what others intend to communicate. So far, there are no interventions that can clearly help people with such symptoms with communication and social function. The purpose of this study is to better understand difficulties with language and social cognition, so that interventions can be developed to improve these.

Our study is designed for individuals between the ages of 15 and 35 who have had psychotic-like experiences. Such experiences include unusual thoughts, suspiciousness, and/or perceptual disturbances, like hearing one’s name in the wind or colors looking different. This study is also available to individuals who have a psychosis diagnosis.

The study involves interviews, computer tests, and brain scans using both magnetic resonance imaging (MRI), which creates pictures of the brain, and electroencephalography (EEG), which records brain waves. Many study visits can take place using a videochat platform for which privacy is maintained. All participants are offered a copy of their initial evaluation.

Who will be conducting the study? Icahn School of Medicine at Mount Sinai

Will subjects be paid (include payment schedule)? Yes. The payment schedule is

1) $70 total for interview and tests;
2) $50 for EEG; and
3) $100 for each of the two MRI sessions, for a total of $200 for MRI.
4) $30 for six-month follow-up visits for interview of 1-2 hours

Please contact Dr. Shaynna Herrera at shaynna.herrera@mssm.edu. More information can be found here:

https://www.cuemountsinai.org

https://www.mountsinai.org/care/behavioral-health/services/schizophrenia/psychosis-risk

When does the post expire? June 2021

The purpose of this study is to determine if taking a pill of estradiol (a form of estrogen) together with prolonged exposure (PE) therapy can improve this treatment outcome in women with Post-Traumatic Stress Disorder (PTSD). Prolonged Exposure (PE) therapy is a validated, evidence-based talk therapy that focuses on helping individuals with PTSD process memories of the trauma. Based on previous findings that the hormone estrogen facilitates people learning not to fear things they had feared before, we want to supplement prolonged exposure therapy with an estradiol pill given before each therapy session. Participants will be randomly assigned to either take estrogen or a placebo (which looks just like the estrogen pill but contains no medicine). Participants will not know which pill they are taking. As part of this study, participants will be asked to go through two separate fMRI scans, one before prolonged exposure therapy treatment and one after. This machine is routinely used by scientists to study the brain and does not use any radiation (x-rays).

The study involves 12 visits to our lab, which is located in midtown east Manhattan, over the course of a 6-9-week period. These visits can be broken down into 2 experimental days, 6 prolonged exposure therapy sessions, and 2 more experimental days. Participation in this study requires 12 visits over six weeks. Six of these visits will be therapy sessions. The other 6 days include assessment visits and going through an emotional learning and memory task before and after therapy. Participants will undergo a fear conditioning procedure that involves receiving an annoying but not painful, half-second electric current applied to the fingers. This procedure will be conducted during two consecutive days. The second day will be conducted in an fMRI scanner. Participants will be paid for their time. Blood samples will be gathered at different time points of the study. There will also be follow-up visits at 3 months and 6 months.

Eligibility criteria: Females between the ages of 18-45 who are taking an oral contraceptive (i.e., birth control)

Is the study therapeutic? Yes – participants will receive free Prolonged Exposure therapy no matter which study arm they are assigned to (i.e., placebo vs estradiol pill).

Is the study funded? Yes, this study is funded by the National Institute of Mental Health (NIMH)

Who will be conducting the study? The study is being conducted at two different sites: Dr. Mohammed Milad is conducting the study within the Department of Psychiatry at NYU Langone Health, and Dr. Edna Foa is conducting the study within the Department of Psychiatry at the University of Pennsylvania Perelman School of Medicine.

Will subjects be paid? Yes – The total compensation for all completed parts will be 480 dollars. Participants will receive 10 dollars for each study visit from visits 1-11 to help defray costs of travel and time. Participants will then receive 270 dollars upon completion of visit 12.

Participants will receive 50 dollars at each remaining follow-up visit. Participants who drop out of the study will be paid for the visits they attended.

Contact information: For more information regarding the study, you can call 1-888-44-WORRY or email Behavioralneuroscience@nyulangone.org. You can also complete the online pre-screening by following this link: https://is.gd/NYU_PTSD_STUDY and a research coordinator will reach out to you with further information about the study.

Post Expiration: The study will be recruiting until June 2023

Investigators at the University of Pittsburgh are doing research that involves a community survey about issues related to the current COVID-19 (coronavirus) pandemic and the experiences of people who are providing unpaid care to a loved one because of an illness (including mental illness), disability, or functional problem. Your responses will inform professionals and policy makers who are designing programs and interventions to help caregivers during this difficult time. We will not ask for your name or any other identifying information, your participation is voluntary, and the survey will take about 20 minutes.

For more information about the survey or to begin taking the survey, please visit the following website: https://bit.ly/PittCOVID19survey

For additional information about the study, please contact Travis Labrum, PhD, LCSW (801-647-3433 or trl51@pitt.edu).

This post will expire in October 2020.

Synexus is performing this study to test study medication that may help individuals aged 18 to 60 years of age, who have been diagnosed with schizophrenia, are experiencing negative symptoms of schizophrenia, and have been clinically stable for at least 6 months. Those who qualify for this study will be performing multiple things like attending 7 visits over a 6-month period, answer questions about their health, obtain blood work and get a physical, and potentially asked to keep a diary throughout the study. The study is therapeutic as there will be study medication at no cost to you. This study is funded by the pharmaceutical company that provides the study medication. Our physicians at Synexus in Queens, New York will be conducting the study at no cost to you. Additionally, compensation for study-related time and travel may be available. For more information, feel free to call Synexus at 718-873-3804, reach out on our Synexus US (Queens) Facebook, or go to our website at www.synexusclinic.com/our-clinics/synexus-queens/.

This post expires 02/20/2021.

Synexus is performing this study to test study medication that may help individuals aged 18 to 65 years of age, who have been diagnosed with schizophrenia, been prescribed and are currently taking an antipsychotic medication treatment for at least 6 months, and have had an inpatient hospitalization for schizophrenia within the last 4 years. Those who qualify for this study will be performing multiple things like attending 6 visits over a 6-month period, answer questions about their health, get a physical, and potentially asked to keep a diary throughout the study. The study is therapeutic as there will be study medication at no cost to you. This study is funded by the pharmaceutical company that provides the study medication. Our physicians at Synexus in Queens, NY will be conducting the study at no cost to you. Compensation for study-related time and travel may be available. For more information, feel free to call Synexus at 718-873-3804, reach out on our Synexus US (Queens) Facebook, or go to our website at www.synexusclinic.com/our-clinics/synexus-queens/.

This post expires 02/20/2021.

The purpose of this outpatient study is to determine the safety and effectiveness of an oral investigational medication, versus placebo, combined with cognitive therapy, for adults with schizophrenia. Those who qualify for this study will be performing multiple things like attending 6 visits up to 20 weeks in duration, answer questions about their health, obtain blood work and get a physical, and potentially asked to keep a diary throughout the study. The study is therapeutic as there will be study medication at no cost to you. This study is funded by the pharmaceutical company that provides the study medication. Our physicians at Synexus Queens, New York will be conducting the study at no cost to the patient. Additionally, compensation for study-related time and travel may be available. For more information, feel free to call Synexus at 718-873-3804, reach out on our Synexus US (Queens) Facebook, or go to our website at www.synexusclinic.com/our-clinics/synexus-queens/.

This post expires 02/20/2021.

This study is a clinical trial of the medication miricorilant. The trial will assess if miricorilant is a safe and effective treatment to reduce body weight in adults with schizophrenia who have gained weight as a result of their antipsychotic medication. The trial will also measure physical health indicators like insulin resistance. The goal of this study is to give people with schizophrenia more options for treatment and management of their physical health.

WHO CAN PARTICIPATE?

Participants may be eligible for this study if they:

• Are between the ages of 18 and 65
• Have a diagnosis of schizophrenia
• Have a BMI (body mass index) of 30 kg/m2 or greater
• Are currently taking the antipsychotic medications olanzapine, risperidone, or quetiapine; and have experienced weight gain while taking the medication

WHERE IS THE STUDY TAKING PLACE?

The study will take place at multiple sites across the United States. There is one site currently recruiting in your area, in: Brooklyn, NY

For a list of sites, please refer to the posting on clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/NCT03818256

HOW DO I LEARN MORE?

For more information, please refer to the posting on clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/NCT03818256

Or contact the study sponsor at study876ctgov@corcept.com.

This study is an anonymous online survey for adults with a mental health condition and their family members/caregivers. The goal of the survey is to understand how much people know about the physical health risks related to mental health conditions and treatments. The survey will ask questions about the participant’s knowledge of physical health and about the care they have received from health care providers. This study will help health care providers improve the ways they educate and support people with mental health conditions.

The study is being conducted by researchers at the University of Massachusetts Lowell and McLean Hospital. The survey takes 15-20 minutes to complete.

Participants may be eligible for this study if they are:

• Aged 18 or older
• Have a mental health condition, or are the family member/ caregiver of a person with a mental health condition

The survey is available online. To access the survey please use the following link: https://umasslowell.co1.qualtrics.com/jfe/form/SV_80MfUYLoMqduzvD

HOW DO I LEARN MORE?
If you have questions or would like more information, please contact the researchers at (978) 934-4471 or Margaret_Knight@uml.edu.

This study is an anonymous online survey being conducted by Dr. Eric Storch, PhD, at the Baylor College of Medicine. The goal of the study is to better understand participants’ thoughts and feelings about Deep Brain Stimulation (DBS) as a treatment option for severe Obsessive Compulsive Disorder (OCD) in adolescents. Understanding the thoughts and feelings of adults with OCD, and of parents who have children with OCD, will support researchers working to improve treatment options in the future.

Individuals may be eligible for this study if they are:

• Adults (aged 18+) with OCD
• Parents (aged 18+) of children with OCD

This study is a 10-15 minute anonymous online survey. Interested individuals can access the survey at this link: https://bcmpsych.sjc1.qualtrics.com/jfe/form/SV_8BQ8l5Q5Sar6dP7.

An introductory letter from the researchers is available via the survey link: https://bcmpsych.sjc1.qualtrics.com/jfe/form/SV_8BQ8l5Q5Sar6dP7.

If you have questions, you may contact the research team at weinzimm@bcm.edu or (713) 798-8563.

Researchers at the Depression and Anxiety Center at the Mount Sinai School of Medicine are seeking study participants to participate in a brain imaging study to investigate if a task can influence depression symptoms.

We are looking for male and female participants who:

• Are 18-45 years old
• Have Major Depression Disorder
• Are not currently taking any anti-depressants

Study participation will include:

• 4-5 study visits (1-5 hours per visit)
• Compensation provided

If you are interested in participating, please take our online pre-screen at https://redcap.mountsinai.org/redcap/surveys/?s=VionGV8Bjh.

Post expires on 5/19/2020

Description: Researchers at the Icahn School of Medicine at Mount Sinai are looking for adults with Panic Disorder, Generalized Anxiety Disorder and/or Post-traumatic Stress Disorder to participate in a brain imaging study. Study investigators hope to learn how the brain is affected by stress and anxiety using new brain imaging technology.

You may be eligible to participate in this study if you:

• Are 18-55 years old
• Have Panic Disorder, Generalized Anxiety Disorder (GAD) or Post-Traumatic Stress Disorder (PTSD)

Participation in this research study includes a study screen and brain scan using magnetic resonance imaging (MRI), which can be done over 1-3 visits. Each study visit is expected to last approximately 2 – 5 hours in length. Subjects will be compensated for their participation.

Contact: If you are interested in participating, please take our online pre-screen at https://redcap.mountsinai.org/redcap/surveys/?s=VionGV8Bjh.

This study will expire in January 2024.

Looking for voluntary research participants who fit the following criteria:

• male or female between 18 and 65 years old
• diagnosed with schizophrenia or schizoaffective disorder

The purpose of this study is to study the effectiveness, safety and tolerability of different doses and durations of an investigational treatment called TV-46000 given by subcutaneous (under the skin) injection as compared to placebo for use as a potential maintenance treatment. TV-46000 is a risperidone extended-release injectable suspension for subcutaneous (sc) use that will deliver therapeutic levels of risperidone over intervals of 1 month (q1m) or 2 months (q2m) to patients with schizophrenia. TV-46000 is a new formulation of risperidone that uses a sustained-delivery technology. TV-46000 is intended to maintain enough levels of risperidone in your body for 1 or 2 months following a single subcutaneous injection. With the injections, a small “depot” of study medication is created under the skin and then the medication is slowly released over time. This is a potential advantage over the currently available two-week injectable form of risperidone. The purpose of the study is to compare the safety and efficacy of different durations of TV-46000 administered subcutaneously versus placebo.

Noncompliance and high discontinuation rates are particularly problematic in patients with schizophrenia. Premature discontinuation of antipsychotic drug therapy is a common phenomenon; in one large study comparing the best available oral medications, 74% of patients discontinued their antipsychotic drug within 18 months due to either poor tolerability or lack of efficacy. Even among patients who do not explicitly discontinue drug therapy, nonadherence to long-term oral medication regimen is one of the most significant therapeutic issues in the therapy of schizophrenia and related disorder. As a result, many of these patients do not experience the full benefit of antipsychotic drug
therapy and suffer frequent relapses or exacerbations that require rehospitalization, often in the context of psychiatric emergency. Thus, the use of a long-acting injectable (LAI) antipsychotic agent may increase compliance in patients with schizophrenia (PSF).

You will receive oral risperidone for 12 weeks and then be randomized (like flipping a coin) to TV- 46000 or placebo. Whether you receive TV-46000 or placebo is decided by chance. You will not learn during the study whether you received TV-46000 or placebo. The study is divided into 3 main parts: Pretreatment, Double-blind Maintenance, and Follow-up/Exit. Pretreatment Period includes the Screening and Stage 1 (Oral Conversion and Stabilization Stage) which has 5 visits and lasts up to 16 weeks. There is an initial screening visit to assess your medical and psychiatric history and symptoms of schizophrenia. You will have a physical exam and blood and urine will be obtained. After you start the study medication, we will monitor your schizophrenia symptoms and overall health throughout the study. You will have visits every 2 weeks during the Pretreatment Period and every week for 12 weeks and then every four weeks thereafter during the Double-Blind Maintenance Stage (open-ended, variable length). Study exit/follow up consists of two visits over 8 weeks.

You will not receive any payment for taking part in the study. To compensate you for your lost productivity associated with attending study visits, we will provide you with a stipend. You will receive a screening stipend in the amount of $75.00 paid via cash. Starting at visit 2, you will receive $75.00 for each clinic visit to compensate for expenses directly related to participation in the Study (such as transportation, meals and parking fees) and $30 for each telephone contact visit through the Greenphire Debit card reimbursement. The stipend for the clinic visits also will serve as reimbursement for travel expenses related to your participation in this study. You do not have to complete the study in order to receive reimbursement for your travel expenses. You will be reimbursed after each completed visit.

Person to Contact: if you have questions or if you would like to participate in this study call 646-774-8496 or e-mail melissa.conant@nyspi.columbia.edu.

When does the study expire?: Data collection for this study began in September 2018 and is scheduled to end in September 2021.

The study is conducted to determine the effects of initial treatment and re-treatment(s) with SAGE-217 in adults with Major Depressive Disorder (MDD) currently experiencing a major depressive episode (MDE) over a 1-year period. Qualified subjects will self-administer SAGE-217 30 mg orally once daily in the evening with food for 14 days.

Number of site visits required: 5 visits

You could be eligible for this study if:

• You have a diagnosis of MDD as diagnosed by SCID-5-CT, with symptoms that have been present for at least a 4-week period.
• You are in good physical health and have no clinically significant findings, as determined by the Investigator, on physical examination, 12-lead ECG, or clinical laboratory tests

You may not be eligible for the study if:

• You have attempted suicide associated with the current episode of MDD.
• You have a medical history of bipolar disorder, schizophrenia, and/or schizoaffective disorder.
• You have had vagus nerve stimulation, electroconvulsive therapy, or has taken ketamine (including esketamine) within the current major depressive episode.

Will subjects be paid? Include amount and payment schedule.: 80 $ per visit

A person to contact, and a website for more general information:
Anastasiya Drovnyashina
Clinical Research Coordinator at Integrative Clinical Trials, LLC
Direct 718.444.7774 Ext: 117
Anastasiya.Drovnyashina@iclinicaltrials.net
www.iclinicaltrials.net

Post expires: 1 year

The purpose of this study is to evaluate the efficacy of adjunctive pimavanserin compared to placebo in subjects with major depressive disorder who have an inadequate response to antidepressant therapy.

The duration of participation for individual study subjects will be up to 14 weeks, consisting of a screening period of up to 4 weeks, a 6-week double-blind treatment period, and a safety follow-up period of at least 30 days. Patients will be given Pimavanserin 34 mg (provided as 2×17 mg tablets) or matching placebo (2×placebo tablets [size- and color-matched to pimavanserin]) to evaluate the efficacy of the study drug to placebo in patients with major depressive disorder.

Number of site visits required: 9 visits

You could be eligible for this study if:

• A clinical diagnosis of major depressive disorder (MDD)
• Is being treated with one of the following SSRI or SNRI antidepressants:
  • Citalopram
  • Escitalopram
  • Paroxetine
  • Fluoxetine
  • Sertraline
  • Duloxetine
  • Venlafaxine
  • Desvenlafaxine
  • Venlafaxine XR
• Inadequate response to SSRI/SNRI antidepressant treatment is confirmed
• If the subject is female, she must not be pregnant or breastfeeding. She must also be of non-childbearing potential OR must agree to use acceptable methods of contraception

You may not be eligible for the study if:

• Has a history of psychotic disorder or is currently being treated or requires treatment for post-traumatic stress disorder, acute stress disorder, panic disorder, or obsessive compulsive disorder
• Has current evidence of an unstable neurological, cardiovascular, respiratory, gastrointestinal, renal, hepatic, hematologic, or other medical disorder, including cancer or malignancies that would affect the patient’s ability to participate in the program
• Has a known history or symptoms of long QT syndrome
• Is determined to be inappropriate for the study for any reason

Additional inclusion/exclusion criteria apply. Patients will be evaluated at screening to ensure that all criteria for study participation are met. Patients may be excluded from the study based on these assessments (and specifically, if it is determined that their baseline health and psychiatric condition do not meet all pre-specified entry criteria).

Will subjects be paid? Include amount and payment schedule.: 80 $ per visit

A person to contact, and a website for more general information:
Anastasiya Drovnyashina
Clinical Research Coordinator at Integrative Clinical Trials, LLC
Direct 718.444.7774 Ext: 117
Anastasiya.Drovnyashina@iclinicaltrials.net
www.iclinicaltrials.net

Post expires: 1 year

Looking for voluntary research participants who fit the following criteria:

• male or female between 18 and 50 years old
• diagnosed with schizophrenia or schizoaffective disorder
• on a stable dose of antipsychotic medication for at least 2 months prior to screening.

Cerevance (CVN058) is an experimental medication that effects the serotonin type 3 receptors in the brain that is being developed for the treatment of cognitive problems in patients with schizophrenia. To date, no specific treatments for cognitive deficits in schizophrenia exist and approved therapies do not satisfactorily improve cognition.

This study will measure naturally occurring brain waves to learn whether CVN058, an investigational drug, may have potential as a new treatment for schizophrenia. This study will also examine whether genetics affects how people respond to CVN058.

The purpose of this study is to determine whether the brain wave patterns are improved after administration of CVN058 compared to placebo in subjects with schizophrenia. The study uses electroencephalography (EEG) to measure naturally occurring brain waves as you listen to recorded sounds. These brain waves can indicate how the brain makes use of auditory information, such as deciding if two tones played one after another are the same or different. Besides MMN, other related brain wave patterns are measured.

Compensation: You will receive a compensation of $50 for the screening visit and $150 for completing each of the 3 treatment periods (that is, $450 for completing all 3 periods). If participating in the optional genetics substudy, you will receive an additional $50. The maximum total amount you may receive for the whole study will be $550. Reasonable and necessary expenses in connection with the study, such as on-site meals, travel and parking, will be reimbursed. A receipt may be required for reimbursement. You will be paid in cash or get a check by mail 4 to 6 weeks after the study.

Person to Contact: if you have questions or if you would like to participate in this study contact Melissa Conant at 646-774-8496 or melissa.conant@nyspi.columbia.edu.

When does the study expire?:  January 2020.

Looking for voluntary research participants who fit the following criteria:

• male or female between 18 and 60 years old
• diagnosed with schizophrenia or schizoaffective disorder
• having side effects or not doing well on current medications

This study plans to learn more about an investigational new drug called ITI-007 (lumateperone tosylate) and may help us to find new types of treatment for schizophrenia and schizoaffective disorder. “Investigational” means that the study drug (ITI-007) has not been approved by the U.S. Food and Drug Administration (FDA), and is considered experimental. There is no placebo (sugar pill) in this study, and everyone will receive ITI-007.

An urgent need exists for new treatments of schizophrenia that are effective against a broad range of symptoms and free of limiting safety issues. ITI-007 (Lumateperone tosylate)is an experimental medication that affects brain proteins that is being developed as a schizophrenia treatment. ITI-007 appeared to work similarly to an FDA approved medication for schizophrenia (risperidone) in a recently published study. The purpose of this study is to offer open label ITI-007 treatment to patients who either poorly respond or poorly tolerate approved medications. A discussion about clozapine will occur during the consent process.

There is no compensation for the study, however you can be reimbursed up to $50 per visit for study related expenses (e.g., travel, food, etc). You may be asked to provide receipts for reimbursement of expenses.

If you have questions or if you would like to participate in this study call 646-774-8496 or e-mail melissa.conant@nyspi.columbia.edu.

Data collection for this study began in March 2019 and is scheduled to end in March 2021.

This study is being conducted by researchers from the Temple University Collaborative on Community Inclusion. The goal of the study is to create guidelines to measure and improve Coordinated Specialty Care (CSC) for psychosis programs. The researchers are interested in how well CSC programs promote and support community participation. To gather this information, they need to hear from people who have been involved with the programs.

Study participants will join a national advisory group to meet via online video conference. Meetings will occur once to twice per month for a period of nine months. The total study period is twenty months. Participants will receive gift cards up to a total value of $600.

This study is seeking three “types” of participants: transition aged-youth, family member, and thought leader.

• Transition aged-youth: aged 18–30, has early psychosis, has been or is involved with a CSC program
• Family member: relative (e.g., parent, sibling, grandparent) or romantic partner of a transition aged-youth who has been or is involved with a CSC program
• Thought leader: program staff (e.g., psychiatrist, social worker, peer specialist), team leader, administrator, director, or trainer who the researchers consider an expert in CSC based on their contributions to the field

The study is seeking 20 total eligible participants.

If you have questions or if you would like to apply to participate in this study, please call the Temple University research staff at (215) 204-1699 or email tucollab@temple.edu.

Improving Cognition via Exercise in Schizophrenia

The goal of this study is to examine the impact of exercise training on cognition, daily functioning, and biomarkers of cognitive change in people diagnosed with schizophrenia and related disorders.

Following an initial research assessment, participants will be assigned by chance to participate in either aerobic exercise training or stretching-and-toning exercise training. Participants in both groups will take part in a 12-week, 3-times per week, 1-hour training program, in addition to their regular psychiatric and/or medical care. All training will be led by a certified trainer in a small group setting. Participants may continue to be treated by their current psychiatrist and/or other mental health clinicians during the study. 

Research assessments will be administered at baseline, and after 6- and 12-weeks of training.  These include diagnostic, clinical and cognitive assessments (interviews, questionnaires, cognitive tasks); fitness assessments and physical activity monitoring; and providing urine and blood samples.

Additional information is available about the study is available at: https://clinicaltrials.gov/ct2/show/NCT03270098?term=NCT03270098&rank=1

Data collection for the study began in May 2018 and is expected to last ~3 years.

Is the study therapeutic? – Yes.

Is the study funded? – Yes, the study is funded by a federal grant from the National Institute of Mental Health, Bethesda, MD (NIMH, Grant #: R01MH110623)

Would subjects be paid? – Eligible participants may receive up to $260 for the completion of the study procedures and research assessment. Participants will also receive reimbursement for travel expenses associated with attending the research assessments and the weekly exercise sessions. 

Contact Information – Interested participants should contact Dr. Luz Ospina, Study Director, at 212-585-4647 orluz.ospina@mssm.edu .

Post expires May 2021.

The primary objective of this study is to understand how brain anatomy relates to function and health. This study is funded by the National Institute of Mental Health and is conducted at New York University School of Medicine, Departments of Radiology and Psychiatry.

We are recruiting 18-30 year old participants who have been diagnosed with schizophrenia or bipolar disorder in the last five years. An initial telephone screening and clinical interview will establish eligibility for the study.

The study involves:

• Clinical assessment
• MRI scanning
• Blood draw
• Cognitive Assessment

This is a non-therapeutic study that does not involve treatment and does not interfere with any ongoing treatments. If eligibility criteria are met, a compensation of $160 will be provided at the completion of the study.

For more information please contact: mariana.lazar@nyumc.org or 212 263-3348.

There is no expiration date for the post at this time.

Do you have a loved one between the ages of 13-17 who has been diagnosed with Schizophrenia or has symptoms of Schizophrenia? Are you interested in joining a clinical research study that may increase our understanding of the disease?

This study is designed to evaluate the safety and efficacy of an investigational drug, called brexpiprazole, for adolescent patients diagnosed with Schizophrenia. The study will compare this medication with an active control (ABILIFY® (aripiprazole)) and placebo.

In order for your child to take part in the clinical research study, you will need to review the full checklist of criteria – found on the eligibility page. Some of the basic criteria that must be met are:

• Be 13-17 years old
• Have a diagnosis or symptoms of schizophrenia that has been confirmed by their doctor
• Do not have a diagnosis of autism, bipolar disorder, schizoaffective disorder, pervasive developmental disorder (PDD), OCD, or PTSD that has been the primary focus of treatment within 3 months of screening.
• Do not have a history of seizures, epilepsy, stroke, or head trauma.

Other requirements will be reviewed in detail with you by the Study Center staff, if your child meets the requirements above and attends a screening visit.

Click here to begin screening.

Currently there are no medications that are approved for Tourette’s Syndrome in Children and Adolescents. Under the supervision of the FDA we are conducting Clinical Trials that involve the use of medications that are already on the market for a different indication.

Here are links with some more information about these trials:

https://clinicaltrials.gov/ct2/show/NCT03530293 for Ingrezza;

https://clinicaltrials.gov/ct2/show/NCT03567291 for Austedo

In order to participate, the patient has to be 6 – 16 years old and both parents and subjects must agree to participate. Patient must meet criteria for Tourette’s Syndrome, even if they have not been diagnosed with Tourette’s Syndrome. The Screening Visit is at no cost to the patient and includes a thorough/extensive physical and neurologic evaluation as well as ECG, Labs and rating scales to confirm the diagnosis of TS.

Transportation and a stipend are provided to the patient. If the subject qualifies for the protocol, a Baseline visit will be scheduled prior to random assignment to one of the treatment groups. At least one parent must accompany the subject at all visits.

Children who participate in the study will receive either the investigation medication or placebo (inactive substance), study-related medical exams, and study-related laboratory services at no charge. Dr. Faedda and research site staff will closely monitor study participants and the information collected. This may lead to future options for managing TS.

For more general information visit the Mood Disorders Center website at https://mdcnyc.com.

To participate and for more information: Contact Yao Ma, Recruiting Specialist Recruitment@mdcnyc.com

Post expires one year, or longer.

Research has shown that genes can make some people more likely than others to develop OCD or Related Disorders. The goal of our study is to identify these genes.

ELIGIBILITY:

• 7 years old or older
• Have symptoms or a diagnosis of Obsessive Compulsive Disorder and Related Disorders (Hoarding Disorder, Body Dysmorphic Disorder, Hair Pulling Disorder/Trichotillomania, and Skin Picking Disorder/Excoriation Disorder)

STUDY PROCEDURES:

• Complete a screening questionnaire on personal and family health history
• Be interviewed by a clinician about your symptoms
• Give a small blood sample (about 3 tablespoons)
• Be compensated for your time and effort
• This is a one-time participation, no follow-up required. Subjects will be paid $50.

Contact Information: Institute for Genomic Health

• InstituteforGenomicHealth@downstate.edu
• 718-270-8254

More information: https://www.downstate.edu/psychiatry/research/index.html
Post expires 7/6/2019

Research has shown that genes can make some people more likely than others to develop Schizophrenia or Bipolar Disorder. The goal of our study is to identify these genes.

ELIGIBILITY:

• 18 years old or older
• Diagnosis of Schizophrenia or Bipolar Disorder

STUDY PROCEDURES:

• Complete a screening questionnaire on personal and family health history
• Be interviewed by a clinician about your symptoms
• Give a small blood sample (about 3 tablespoons)
• Be compensated for your time and effort
• This is a one-time participation, no follow-up required. Subjects will be paid $50.

Contact Information: Institute for Genomic Health

• InstituteforGenomicHealth@downstate.edu
• 718-270-8254

More information: https://www.downstate.edu/psychiatry/research/index.html
Post expires 7/6/2019

The purpose of this study is to investigate the relationship between aging processes and PTSD, which may help identify novel therapeutic targets to promote healthier aging trajectories for PTSD patients. Chronic PTSD increases mortality risk from medical diseases, promotes aging-associated syndromes such as frailty, and is linked to faster cognitive decline in older adults. One strong possibility is that PTSD leads to these adverse health outcomes by accelerating biological aging in the brain and body.

Participants will be asked to attend a total of 3 visits consisting of: an evaluation, an MRI, and a day of neuropsychological testing.

To compensate for the time required for the eligibility evaluation, we offer $50 cash upon completion. Additionally, you will be paid $300 if you complete all procedures in this study, including the two additional study visits. Payment will take place in the form of a check.

To participate and for more information: Contact Chloe Salzman at 646-774-8655

The purpose of this study is to determine whether treating hearing loss is helpful for depression over and above the known effects of antidepressants. Age-related hearing loss (ARHL) is the third most common health condition affecting older adults after heart disease and arthritis and is the fifth leading cause of years lived with disability worldwide. Many hearing-impaired older adults avoid or withdraw from social contexts in which background noise will make it difficult to communicate, resulting in social isolation and reduced communication with family and friends. Social isolation and loneliness have been linked to numerous adverse physical and mental health outcomes, including dementia, depression, and mortality, and they may also lead to declining physical activity and the development of the syndrome of frailty.

In this research study, participants may be fitted with free hearing aids. They will also receive treatment for depression with an FDA approved medication called escitalopram (Lexapro) or duloxetine (Cymbalta). Escitalopram is a Selective Serotonin Reuptake Inhibitor (SSRI) medication, and duloxetine is a Selective Serotonin-Norepinephrine Reuptake Inhibitor (SSNRI) that both appear to help with symptoms of depression. Participants will attend study visits to monitor progress and ensure safety over the course of participation. Participants may also be offered brain scans using magnetic resonance imaging (MRI).

• To participate, individuals must be 60 years or older.
• We offer $50 for the completion of each MRI scan. We also offer reasonable compensation for travel costs related to study participation. Participants may also receive free hearing aids listed at a price of $6,000.
• To participate and for more information: Contact Alexandra Stein at 646-774-8672

In this research study, participants may receive treatment for depression with an FDA approved medication called escitalopram (Lexapro) or placebo. Escitalopram is a Selective Serotonin Reuptake Inhibitor (SSRI) medication that appears to help with symptoms of depression by increasing the availability of specific chemicals in the brain. A placebo is a sugar pill. This study is looking at treatment response in adults ages 18-75. Participants will attend study visits and receive phone calls from staff to monitor progress and ensure safety over the course of participation.

• Subjects may receive up to $300 in compensation over the course of participation.
• To participate and for more information: Contact Stuart Fine at 646-774-8670

Individuals with Late Life Depression (LLD) often have problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response. Available evidence suggests that declining functionality in the brain’s dopamine system contributes to age-related cognitive and motor slowing. The purpose of this research study is to test whether a medication called carbidopa/levodopa (Sinemet) is helpful for the treatment of depression in older adults. Carbidopa/levodopa is approved by the Food and Drug Administration for the treatment of Parkinson’s Disease. We are using carbidopa/levodopa in this study to see whether it is capable of improving depressive symptoms as well as mental and physical slowing that occur as people age.

• Participants will be prescribed carbidopa/levodopa (Sinemet) by the study psychiatrist, free of charge. Progress will be monitored through weekly visits with the study staff for 8 weeks. Participants may also be offered brain scans using magnetic resonance imaging (MRI) and positron emission tomography (PET).
• To participate, individuals must be 60 years or older.
• Contact Emily Valente at 646-774-6704 for more information or to sign up.

Treatment-resistant depression (TRD) is a major health problem for the growing population of older adults. Unfortunately, there is a lack of evidence-based treatments that establish the benefits vs. risk of medication in this patient population. The purpose of this research study is to find out which antidepressants work best in individuals over the age of 60 who did not respond or were intolerant to at least two antidepressant medications. The study offers treatment with FDA approved medications: aripiprazole, bupropion, lithium, and nortriptyline.

• Participants will be prescribed medication by the study psychiatrist. Progress will be monitored through biweekly phone calls or visits with the study staff. Participants will be asked to complete neuropsychological assessments, answer questions about their mood, and report medication tolerance.
• To participate, individuals must be 60 years or older.
• Subjects are paid $50 for completing initial evaluation. If found eligible and enrolled into the study, subjects receive $75 at the baseline visit, $75 at the end of 10-weeks of treatment, and $25 at each of 3 follow up visits after completing the initial 10 weeks of acute treatment.
• For more information: Stephanie Gomez at 646-774-8698 or Sandra Sanchez for service in Spanish at 646-774-8692
• Read more here: www.optimumstudy.org/for-participants.html
• This study will continue to recruit for the next 3 years.

Depression affects up to 20% of the population in a given year. We’re asking patients to provide a short speech sample and complete a survey (e.g. a modified PHQ-9 score) so we can determine whether an individual is depressed from acoustic and linguistic features. By being a part of the study as a patient or a control, you will help us build better algorithms to detect depression symptoms from voice samples.

Patients can participate on laptops, tablets, or mobile devices: https://mha.neurolex.ai. You can also try a demo: http://collect.neurolex.ai.

By analyzing short voice samples for unique health characteristics, our technology discovers specific speech variations that indicate different health abnormalities earlier than previously possible. These new, proprietary tools give patients and providers greater visibility into their overall well-being, enabling early action to prevent symptoms from worsening.

At NeuroLex we are empowering patients with tools to measure their overall health through collecting and analyzing speech samples. By fingerprinting health abnormalities early, we equip patients and physicians with insight to prevent symptoms from worsening. In this way, we strive to be the world’s leading platform company to advance linguistics as a tool to characterize psychiatric and neurological health conditions.

Is the study therapeutic (offering treatment)? Non-therapeutic

Is the study funded? This research study is funded internally by NeuroLex Laboratories, a for-profit company. There are no disclosed ties to the pharmaceutical industry. We are actively pursuing government grants like SBIRs to further our work.

Who will be conducting the study? NeuroLex is conducting the study in close collaboration with several academic partners.

Go to NeuroLex to read more about the company and the technology.

The Schizophrenia Research Program at NYU Langone Health, is currently seeking individuals (ages 16-30) with a diagnosis of schizophrenia, schizotypal, or schizophreniform disorder who have not taken antipsychotic medication for at least 4 weeks to participate in our research study funded by the National Institute of Mental Health.

In our study, we are looking for an alternative treatment for individuals with early psychosis. We are trying to see if a single dose of an anticonvulsant medication may be able to quiet down a specific part of the brain.

The study involves:

• Two study visits
• Two brain imaging scans
• One single dose of Keppra (an FDA approved anticonvulsant medication) or placebo.

If eligibility criteria are met, participants will receive $200 for the completion of the study in addition to reimbursement for travel. If you are interested in participating or want more information please call or text our study team at (917) 565-1581 or email us at GoffLab@nyumc.org.

This study is looking at whether an investigational medication called BI 409306 is safe and effective in reducing the early symptoms of psychosis. The goal of this study is to increase treatment options available for people experiencing the early symptoms of psychosis.

Participants may be eligible for this study if they are:

• 16-30 years old
• Experiencing early symptoms of psychosis
• Have not yet experienced a first episode of psychosis

If you have questions or would like more information, please refer to the trial website (https://1289-0032study.com)

This study is an anonymous online survey that looks at tobacco use by people who experience mental health conditions. The goal of this study is to give researchers more information about how many people in this population use tobacco, how many would like to quit using tobacco, and some of the important experiences and feelings involved. Collecting this information is very important to support future research in tobacco cessation.

Participants may be eligible for this study if they:

• Are 18 years or older
• Have been diagnosed with a mental health condition

Please select this link to access the survey: https://uofmississippi.qualtrics.com/jfe/form/SV_0cuRZjHQUM5BZLD

If you have questions about this study, you may contact the research team directly. Dr. Joshua Mann can be reached at jmann4@umc.edu.

We are a behavioral health startup based in New York City.  We are currently developing a self-directed cognitive behavioral therapy app for iOS and Android devices to help individuals better manage their stress, anxiety, and mood.  The app consists of a six-week interactive curriculum written by clinical psychologists.  Through educational material and homework assignments, the app teaches users to differentiate between their thoughts and feelings, and to develop healthy self-care behaviors.

We are currently conducting a consumer-focused product research and are looking for participants to take part in a focus group which would give participants the opportunity to play around with the app and provide feedback.

Participation in our research consists of an in-person interview at a WeWork office in New York City during the month of September.  The interview will take no longer than 60 minutes and participants will be compensated.

To participate individuals must:

• Be 18 years or older
• Have a smartphone
• Have, or have had private health insurance
• And be interested in managing their mood, reducing stress, or increasing their happiness

To see if you qualify, please take this survey: https://digitalhealth1.typeform.com/to/XPSJBW.

For questions, email research.digital.health@gmail.com.

To date, very little is known about client and family experiences following discharge from specialized first episode psychosis/early intervention programs (like OnTrack) or how to best support them. This study aims to better understand what happens after discharge from OnTrack, including in the areas of school or work involvement and access to/use of other mental health services.

Who Is Eligible: Any family member of a former OnTrack client who has been discharged at least one year prior to a scheduled interview is eligible. Former clients will be recruited for the project through the OnTrack sites at which they initially received services.

Study Activity & Time Involved: If interested, you would be asked to participate in an approximately 1.5 hour long oral interview by phone or in person. This is not a treatment study.

Compensation: You will be compensated $75 for your time.

Who to Contact: To ask any questions or get involved, please contact Dr. Jones directly at 773-639-8360 or by email at genevra@usf.edu.

In this study, local doctors are evaluating an investigational drug that is being developed for the treatment of manic episodes. They want to compare the investigational drug to placebo, which looks like the investigational drug, but contains no active medication

The investigational drug is currently approved in Canada and the United States for the treatment of schizophrenia. It is also approved in the United States as an added treatment to antidepressants for major depressive disorder. It has not been approved anywhere to treat manic episodes related to bipolar disorder. The results of this study will help provide more information about the investigational drug and whether it could one day be used as a treatment for manic episodes.

Who is eligible to participate in this study? To pre-qualify for this study, you must:

• Be 18 to 65 years of age
• Have been diagnosed with bipolar I disorder
• Be having symptoms of a manic episode

All study-related visits, tests, and drugs will be provided at no cost. In addition, reimbursement for study-related travel may be provided.

To see if you are eligible for this study, please click here: leapcurebipolardisorder.studies.leapcure.com

A Double-Blind, Placebo-Controlled Study of Brexpiprazole plus Ketamine in Treatment-Resistant Depression (TRD)

Montefiore Medical Center is seeking patients with major depressive disorder (MDD) between the ages of 18 and 65 to participate in a new depression research study.

Dr. Jonathan Alpert is conducting this research to assess if the combination of brexpiprazole and intranasal ketamine can safely and effectively treat depression symptoms when added to stable, ongoing antidepressant treatment.  Ketamine is approved by the U.S. Food and Drug Administration (FDA) to be used with other drugs for anesthesia and as a pain reliever during procedures.  However, ketamine is not approved by the FDA to treat depression.  Brexpiprazole (Rexulti) is approved by the U.S. Food and Drug Administration (FDA) as an add-on treatment to an antidepressant medication to treat adults with major depressive disorder (MDD).  Participants will receive either the active study medication (1/2 chance of receiving brexiprazole) plus 40 mg of ketamine administered intranasally ,  or placebo (1/2 chance of receiving placebo) plus 40 mg of ketamine administered intranasally.  Participants will be monitored by an experienced study physician.  The study requires 12 visits to our research clinic over a period of 5 to 8 weeks, depending on the length of the screening portion.

Participants will receive compensation for their time.  You will be paid $450 if you complete the study.  If you do not complete the study, you will be paid for each visit you complete.

Please contact Jennifer Alexander if you or someone you know is interested in learning more about this study.

Jennifer Alexander
929-429-5644
jealexan@montefiore.org

Does your child struggle to stay organized?

Many children with conditions like Attention-Deficit/Hyperactivity Disorder (ADHD) struggle to stay organized, manage their time, and plan activities. Even when ADHD is being well treated, organizational problems can cause difficulties in school and create headaches at home.

Children in grades 3-5 (who have one main teacher) are being recruited for a therapeutic study on brain function at the NYU Child Study Center funded by the National Institute of Mental Health.

Children must show difficulty with organization, time management or planning.

The study will include

• a brief no-cost assessment
• two brain MRI scans at NYU
• a no-cost weekly individualized treatment for 12 weeks

Participants will be compensated $75 for the initial evaluation and $75 for each of the two MRI scan sessions.

For more information, please contact us at (646) 754-5147 or csc.organizedkids@nyumc.org, or visit our website: bit.ly/organized-kids.